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FAQ

Most frequent questions and answers

Product

Mesenchymal stem cells originating from bone marrow are the most powerful and versatile population in your body, able to transform into myriad cell types to fight injury and inflammation. As they leave the bone marrow and travel throughout the body, these stem cells act as command and control centers, directing the process of healing to minimize overall damage.

AnteAGE MD restores your skin’s ability to heal itself through its unique combination of Stem CytokinesTM (stem cells) and two Growth Factors. AnteAGE MD reduces the appearance of fine lines and wrinkles, creates a visible brightening and lifting effect, and prevents new visible signs of aging.
 
We use Stem CytokinesTM derived from human bone marrow stem cells which are cultured and harvested in our lab.

Growth factors extracted from adult bone marrow contain anti-inflammatory growth factors at high percentages, making them ideal for healthy skin.

AnteAGE Accelerator and Serum contain substances that are foreign to the skin and should not be used during microneedling or for several hours after the treatment when the microchannels have closed. We offer AnteAGE Microneedling Solution intended for use with microneedling, which contains no antigenic material and consists only of proprietary blend of stem cell cytokines and growth factors in a high molecular weight hyaluronic acid base.
Platelet Rich Plasma includes hundreds of cytokines, many of which are pro-inflammatory. Our opinion remains that PRP incites a significant pro-inflammatory response when used in conjunction with microneedling, and that this may be something to avoid, especially in individuals prone to hyperpigmentation or fibrosis. On an occasional basis, most people should tolerate PRP without problem or difficulty. However, the amount of cytokines and growth factors declines with age, which is why healing times are longer the older we grow. This means that most patients seeking these treatments will not have the same concentration of anti-inflammatory cytokines and growth factors in their plasma that are contained in AnteAGE Microneedling Solution.
Some results take time to achieve, and others happen quite fast. Some users see results in as little as 4 days. Typically, most people see noticeable results within 30 days. Most importantly, you’re preventing new visible signs of aging every day when you use the AnteAGE system.

Due to pressure changes and other environmental factors, our airless pumps may act up from time to time. Please follow the steps in the video below to resolve this issue:

 

Stem Cells

Live stem cells are not used in AnteAGE. Rather, we grow human bone marrow stem cells under special conditions in labs and then extract only cytokines and growth factors, discarding everything else. AnteAGE products contain these cytokines and growth factors, which are proteins encapsulated in natural lipid envelopes to preserve them, keep them functional, and aid in transporting these rejuvenating agents.

No, neither. Our stem cells are sourced only from the bone marrow of young, healthy, pre-screened adult donors. Stem cell cytokines also contain none of the original cell parts themselves, only the beneficial growth factors they produce.

We source our stem cells from the bone marrow of young, healthy, pre-screened adult donors. The cells are cultured in a laboratory, within a controlled environment that fosters production of the biosignals that will engage in skin repair and rejuvenation. We then harvest and extract the powerful growth factors and cytokines inside, discarding the cell itself. Our products are 100% free of inflammatory cells, cell fragments, RNA, or DNA.
Mesenchymal stem cells originating from bone marrow are the most powerful and versatile population in your body, able to transform into myriad cell types to fight injury and inflammation. As they leave the bone marrow and travel throughout the body, these stem cells act as command and control centers, directing the process of healing to minimize overall damage. We can’t live without these cells, and yet we have fewer of them working for us with each passing day. Cellese Regenerative Therapeutics cultures these cells in-vitro, providing them with a controlled environment to foster production of biosignals engaged in skin repair and rejuvenation. We harvest these Growth Factors & Cytokines they produce and use them as our products’ primary active.

Mesenchymal stem cells (MSC) are special types of stem cells that are pluripotent and can differentiate into a variety of cell types including bone, cartilage, and muscles. They direct reparative biochemical functions by secreting a pattern of biosignals called cytokines, which begin a chain of communication with other cells to perform tasks that are orchestrated by the MSCs. The concentration and specific cytokine patterns they generate depends on the physiologic role from where they are sourced. This means that adipose-derived stem cells are programmed to produce new fat cells, and bone marrow stem cells are programmed to migrate to injuries and to regenerate new bone, tissue, or cartilage. However, in labs they can be manipulated and triggered to perform specific tasks regardless of their origin, such as generating elastin or fibroblasts despite originating from bone marrow.

All bone marrow stem cells used to cultivate our biosignals and growth factors are from adult female donors. They are ethically sourced from state of the art, certified laboratories.

Plant stem cells do not produce signals that can communicate with human cells, and human cells do not have receptors for plant biochemicals. Because they cannot communicate with each other, plant stem cells are unable to influence human cellular activity or stimulate a direct cellular response to grow new tissue, such as collagen. Plant stem cells act as antioxidants in skincare products, and—like many antioxidants commercially available—can offer an anti-inflammatory effect, protect against UV-induced oxidative stress, and can nourish skin cells. The American Academy of Dermatology has outlined the role plant stem cells play in skincare. https://www.aad.org/media/news-releases/new-technology-could-make-antioxidants-in-skin-care-products-more-effective

Conditioned media is the blend of nutrients that remain after filtering cells for unwanted materials.
Stem cells are not all alike. The scientists that developed AnteAGE believe that bone marrow stem cells are the most effective source because they are what command and control tissue repair and healing throughout the body. Unlike bone marrow stem cells, adipose (lipid or fat) derived stem cells are not programmed towards wound repair, and are primarily used to generate more fat cells. They also contain more pro-inflammatory pattern of cytokines and growth factors, and inflammation is not something AnteAGE believes should be promoted in skin on a daily basis. Bone marrow stem cells do the opposite by countering and calming inflammation. Fibroblasts are connective tissue in the body that produces collagen, but are not stem cells. In cosmetics, they have typically been sourced from human foreskins. Although they aren’t stem cells, fibroblasts produce some biosignals, but not as many as bone marrow stem cells, which can be 15 to 50 times more bountiful.
Very few ingredients are able to reach the dermis where stem cells reside to active them. However, irritation will trigger an immune response in the body that will activate stem cells to identify damage and migrate to injured areas to begin reparative cellular activity. This means that any pro-inflammatory ingredient that irritates skin or induces an allergic reaction could be considered a stem cell activator because stem cells in skin are a defense mechanism that detects damage and responds by migrating to injured cells and creating healing cytokines, growth factors, and mRNAs.

Growth Factors & Cytokines

Growth factors are subset of cytokines with extracellular polypeptide proteins found in a variety of cellular processes, such cell growth and migration, and are integral in wound repair.
Inflammatory cytokines may be helpful to begin the injury repair process, but you want to quickly transition from inflammatory to anti-inflammatory (the so-called regenerative phase of wound healing). If you stay in an inflammatory state for prolonged periods, you may get scars, rigid fibroblasts, poor cross linking on collagen fibers, high levels of proteases, which accelerates the appearance of aging rather than being anti-aging. In microneedling treatments, the needles that penetrate the skin induce an inflammatory response that will generate pro-inflammatory cytokines, so there is no need to add more. However, healing duration will be shorter with additional anti-inflammatory cytokines.
This is the proprietary blend of growth factors and cytokines extracted from bone marrow stem cells used in AnteAGE, and are the biosignals that can communicate with human cells.
Many clients are told by physicians or aestheticians that stem cells are too large to reach the dermis. Although a stem cell may be too large, AnteAGE contains only the cytokines and growth factors that are extracted from stem cells, and uses liposomonal technology to ensure that these microscopic molecules can slip between epidermal cells to reach skin repairing cells. We wrap all our GF & cytokine proteins in lipid envelopes (nano-liposomes), and add other penetration enhancers and autocrine amplifiers.
Growth factors derived from humans can be used during microneedling because they are biogenic and will not cause an allergic reaction. They are a byproduct of cellular conditioned media, and neither contain nor transmit DNA or diseases.
Epidermal growth factor (EGF) is a family of cytokines involved in the growth, development, and healing of damaged or dead tissues. There are several EGFs that reside in the dermis and are triggered later in the skin regeneration process. However, topically applied EGFs can induce the outer or epidermal layer of skin cells to multiply and thicken the skin.
Bio-identical growth factors are proteins that have been combined to create a molecular structure that is identical to what is found in human sources and have the same effect. Some recombinant growth factors are included in AnteAGE to supplement the broad range of biologic proteins found in humans. However, there are only a few commercially and economically available, and therefore do not fully replicate the blend that can be sourced in bone marrow stem cells.
For skin the most important cytokines (actually families of cytokines, each with multiple members) are epidermal growth factor (EGF) family, transforming growth factor beta (TGF-beta) family, fibroblast growth factor (FGF) family, vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating factor (GM-CSF), platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF), interleukin (IL) family, and tumor necrosis factor-alpha family.